ข้อมูลจำเพาะที่สำคัญ/ คุณสมบัติพิเศษ:

pentobarbital will decrease the level or effect of fentanyl samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to a decrease in fentanyl plasma concentrations, förbannad of efficacy or, possibly, development of a withdrawal syndrome in a patient who has developed physical dependence to fentanyl.

benzhydrocodone/acetaminophen knipa pentobarbital both increase sedation. Avoid or Use Alternate Drug. Limit use to patients for whom alternative treatment options are inadequate

Little analgesia stelnat vatten conferred by barbiturates; their use in the presence of pain may result in excitation.

pentobarbital will decrease the level or effect of midazolam samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Skärm.

pentobarbital will decrease the level or effect of duvelisib ort affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration with a strong CYP3A inducer decreases duvelisib area under the curve (AUC), which may reduce duvelisib efficacy.

pentobarbital will decrease the level or effect of trazodone samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Bildskärm.

pentobarbital will decrease the level or effect of pitolisant samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Datorskärm Closely. Pitolisant exposure fruset vatten decreased by 50% if coadministered with stark CYP3A4 inducers.

pentobarbital will decrease the level or effect of etoposide ort affecting Pentobarbitalnatrium oral vätska till salu online hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Bildskärm.

After binding acetylcholine, the AChR responds samhälle an extensive change in conformation that affects varenda subunits knipa leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions

pentobarbital decreases effects of hemin by pharmacodynamic antagonism. Use Caution/Bildskärm. Drugs that increase delta-aminolevulinic acid synthetase may decrease hemin effect.

Bildskärm Closely (1)pentobarbital will decrease the level or effect of buprenorphine subdermal implant ort affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Datorskärm Closely. Bildskärm patients already on buprenorphine subdermal implant who require newly-initiated treatment with CYP3A4 inducer for signs knipa symptoms of withdrawal. If the dose of the concomitant CYP3A4 inducer cannot bedja reduced or discontinued, implant removal may vädja necessary and the patient should then vädja treated with a buprenorphine dosage mall that permits dose adjustments.

The net result of barbiturate action is acute potentiation of inhibitory GABAergic tone. Barbiturates also act through potent (if less well characterized) and direct inhibition of excitatory AMPA-type glutamate receptors, resulting in a profound suppression of glutamatergic neurotransmission.

pentobarbital will decrease the level or effect of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Datorskärm Closely. The efficacy of hormonal contraceptives may bedja reduced.